Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

A simple method for displaying the hydropathic character of a protein

Jack Kyte, Russell F. Doolittle · Journal of Molecular Biology · 1982 · 22.9K citations

Protein Chemistry, Biochemistry, Simple Method +12

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature · 1987 · 4.6K citations

Alzheimer's Disease, Protein Folding, Cell-surface Receptor +7

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

J. Garnier, David J. Osguthorpe, Barry Robson · Journal of Molecular Biology · 1978 · 4.6K citations

Structural Bioinformatics, Biomolecular Structure Prediction, Protein Folding +13

Strategies for multilocus linkage analysis in humans.

G.M. Lathrop, J.-M. Lalouel, Cécile Julier et al. · Proceedings of the National Academy of Sciences · 1984 · 2.6K citations · Full text

Genetic Analysis, Linkage Disequilibrium, Genotype-phenotype Association +14

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

George G. Glenner, Caine W. Wong · Biochemical and Biophysical Research Communications · 1984 · 1.7K citations

Down Syndrome, Alzheimer's Disease, Dementia +10