Concepedia

Seeded Aggregation

Seeded Aggregation is a biochemical mechanism in protein aggregation disorders whereby pre-formed aggregates or fibril fragments act as templates to accelerate the conformational conversion and assembly of soluble protein monomers into ordered amyloid structures.

69

Publications

5.5K

Citations

424

Authors

182

Institutions

Publications per year

2017–2026

37

Parents

Publications

69

Automatic image segmentation by integrating color-edge extraction and seeded region growing

Jianping Fan, David K. Y. Yau, Ahmed K. Elmagarmid et al. · IEEE Transactions on Image Processing · 2001 · 573 citations

, , +16

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-β protein

James D. Harper, Charles M. Lieber, Peter T. Lansbury · Chemistry & Biology · 1997 · 452 citations · Full text

, , +17

Role of α-Synuclein Carboxy-Terminus on Fibril Formation in Vitro

Ian Murray, Benoit I. Giasson, Shawn M. Quinn et al. · Biochemistry · 2003 · 359 citations

, , +17

Seeded Aggregation and Toxicity of α-Synuclein and Tau

Takashi Nonaka, Sayuri Watanabe, Takeshi Iwatsubo et al. · Journal of Biological Chemistry · 2010 · 335 citations · Full text

, , +17

A kinetic study of β‐lactoglobulin amyloid fibril formation promoted by urea

Daizo Hamada, Christopher M. Dobson · Protein Science · 2002 · 277 citations · Full text

, , +17

1–5 of 69

Authors

424

  1. RM
    Ronald Melki

    Centre National de la Recherche Scientifique, France

    4 publications · 242 citations

    4

    h-index

  2. SV
    Salvador Ventura

    Universitat Autònoma de Barcelona, Spain

    3 publications · 58 citations

    3

    h-index

  3. BJ
    Benjamin J. Tuck

    University of Cambridge, United Kingdom

    3 publications · 89 citations

    3

    h-index

  4. MH
    Masato Hasegawa

    Tokyo Metropolitan Institute of Medical Science, Japan

    3 publications · 489 citations

    3

    h-index

  5. WA
    William A. McEwan

    MRC Laboratory of Molecular Biology, United Kingdom

    3 publications · 89 citations

    3

    h-index

1–5 of 424

Institutions

182

  1. University of Cambridge

    Cambridge, United Kingdom

    8 h-index

    52 publications

    4.5K citations

  2. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    4 h-index

    8 publications

    539 citations

  3. German Center for Neurodegenerative Diseases

    Bonn, Germany

    4 h-index

    21 publications

    1.1K citations

  4. University of California, Los Angeles

    Los Angeles, United States

    4 h-index

    22 publications

    1.1K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    13 publications

    911 citations

  6. UK Dementia Research Institute

    London, United Kingdom

    4 h-index

    26 publications

    856 citations

  7. Direction de la Recherche Fondamentale

    Gif-sur-Yvette, France

    3 h-index

    7 publications

    507 citations

  8. University of Twente

    Enschede, The Netherlands

    3 h-index

    8 publications

    358 citations

1–8 of 182

Venues

  1. Journal of Biological Chemistry

    JBC · 5 publications · 764 citations

    5

    h-index

  2. Acta Neuropathologica Communications

    3 publications · 148 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 347 citations

    3

    h-index

  4. Nature Communications

    3 publications · 298 citations

    3

    h-index

  5. FEBS Letters

    3 publications · 110 citations

    3

    h-index

1–5