Concepedia

Aggregate Propagation

Aggregate Propagation is a pathogenic mechanism in protein aggregation disorders characterized by the cell-to-cell transmission and subsequent seeding of misfolded protein aggregates, distinguishing it from intrinsic aggregation processes by its capacity for spatial progression and network-based dissemination within tissues.

17

Publications

1.3K

Citations

107

Authors

53

Institutions

Publications per year

2017–2026

10

Parents

Publications

17

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

Najla Kfoury, Brandon B. Holmes, Hong Jiang et al. · Journal of Biological Chemistry · 2012 · 557 citations · Full text

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Transcellular spreading of huntingtin aggregates in the <i>Drosophila</i> brain

Daniel T. Babcock, Barry Ganetzky · Proceedings of the National Academy of Sciences · 2015 · 126 citations · Full text

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The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Josquin Courte, Luc Bousset, Ysander von Boxberg et al. · Scientific Reports · 2020 · 85 citations · Full text

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Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

GuoZhen Wang, Alan R. Fersht · Proceedings of the National Academy of Sciences · 2015 · 78 citations · Full text

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Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

Dong‐Kyu Kim, Hee-Sun Lim, Ichiro Kawasaki et al. · Autophagy · 2016 · 72 citations · Full text

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1–5 of 17

Authors

107

  1. JC
    Jason C. Sang

    University of Cambridge, United Kingdom

    2 publications · 81 citations

    2

    h-index

  2. GM
    Georg Meisl

    University of Cambridge, United Kingdom

    2 publications · 81 citations

    2

    h-index

  3. TP
    Tuomas P. J. Knowles

    University of Cambridge, United Kingdom

    2 publications · 53 citations

    2

    h-index

  4. DK
    David Klenerman

    University of Cambridge, United Kingdom

    2 publications · 81 citations

    2

    h-index

  5. MD
    Monica Driscoll

    Rutgers, The State University of New Jersey, United States

    1 publications · 26 citations

    1

    h-index

1–5 of 107

Institutions

53

  1. University of Cambridge

    Cambridge, United Kingdom

    3 h-index

    23 publications

    739 citations

  2. University of Oxford

    Oxford, United Kingdom

    2 h-index

    2 publications

    80 citations

  3. Inserm

    Paris, France

    2 h-index

    10 publications

    416 citations

  4. Harvard University

    Cambridge, United States

    1 h-index

    3 publications

    63 citations

  5. Mathematical Institute of the Slovak Academy of Sciences

    Bratislava, Slovakia

    1 h-index

    1 publications

    67 citations

  6. Albert Einstein College of Medicine

    Bronx, United States

    1 h-index

    2 publications

    52 citations

  7. Konkuk University Medical Center

    Seoul, South Korea

    1 h-index

    5 publications

    360 citations

  8. Eli Lilly (United Kingdom)

    Basingstoke, United Kingdom

    1 h-index

    8 publications

    280 citations

1–8 of 53

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 242 citations

    3

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 592 citations

    2

    h-index

  3. Journal of Theoretical Biology

    1 publications · 67 citations

    1

    h-index

  4. Journal of the American Chemical Society

    JACS · 1 publications · 32 citations

    1

    h-index

  5. Physical Review Letters

    PRL · 1 publications · 21 citations

    1

    h-index

1–5