Oligomer Toxicity is a pathological mechanism in protein misfolding diseases characterized by the toxic effects exerted by transient, soluble oligomeric aggregates of misfolded proteins, which disrupt cellular homeostasis through mechanisms such as membrane permeabilization, organelle dysfunction, and aberrant molecular interactions, distinguishing it from the comparatively inert or structurally ordered aggregates like amyloid fibrils.
355
Publications
38.4K
Citations
2.1K
Authors
648
Institutions
Publications per year
2017–2026
122
Publications
355
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature · 2002 · 2.4K citations
In vivo demonstration that α-synuclein oligomers are toxic
Beate Winner, Roberto Jappelli, Samir K. Maji et al. · Proceedings of the National Academy of Sciences · 2011 · 1.5K citations · Full text
Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
Pascale N. Lacor, Maria C. Buniel, Lei Chang et al. · Journal of Neuroscience · 2004 · 955 citations · Full text
1–5 of 355
Authors
2.1K
- FC
19
h-index
- CM
17
h-index
- RC
16
h-index
- CC
16
h-index
- MV
14
h-index
1–5 of 2.1K
Institutions
648
University of Cambridge
Cambridge, United Kingdom
26 h-index
171 publications
26.5K citations
University of Florence
Florence, Italy
24 h-index
135 publications
33.7K citations
University of California, Irvine
Irvine, United States
16 h-index
38 publications
39.5K citations
Northwestern University
Evanston, United States
15 h-index
57 publications
14.4K citations
Harvard University
Cambridge, United States
11 h-index
28 publications
6K citations
National Research Council
Rome, Italy
11 h-index
27 publications
1.3K citations
Aarhus University
Aarhus, Denmark
11 h-index
65 publications
5.2K citations
University of California, Los Angeles
Los Angeles, United States
9 h-index
55 publications
13K citations
1–8 of 648
Venues
- Journal of Biological Chemistry
JBC · 18 publications · 3.4K citations
18
h-index
- PLoS ONE
20 publications · 1.9K citations
18
h-index
- Proceedings of the National Academy of Sciences
PNAS · 15 publications · 3.9K citations
15
h-index
- ACS Chemical Neuroscience
16 publications · 420 citations
14
h-index
- Scientific Reports
11 publications · 691 citations
11
h-index
1–5