Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Mary P. Lambert, Avlin Barlow, Brett A. Chromy et al. · Proceedings of the National Academy of Sciences · 1998 · 3.5K citations · Full text

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Oxford Textbook of Medicine.

Annals of Internal Medicine · 1988 · 1.6K citations

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Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Kelly A. Conway, Seung‐Jae Lee, Jean‐Christophe Rochet et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +17

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

Alfredo Lorenzo, Bruce A. Yankner · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Albert Y. Hsia, Eliezer Masliah, Lisa McConlogue et al. · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17