Aggregation-Induced Toxicity is a pathophysiological phenomenon in which the accumulation of misfolded protein aggregates disrupts cellular homeostasis and induces cytotoxic effects, primarily through membrane damage, organelle dysfunction, and dysregulation of proteostasis networks.
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209
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2017–2026
25
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Publications
93
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature · 2002 · 2.4K citations
Opposing Activities Protect Against Age-Onset Proteotoxicity
Ehud Cohen, Jan Bieschke, Rhonda M. Perciavalle et al. · Science · 2006 · 858 citations · Full text
1–5 of 93
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510
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1–5 of 510
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209
University of Cambridge
Cambridge, United Kingdom
6 h-index
20 publications
9.6K citations
University of Florence
Florence, Italy
4 h-index
22 publications
21.2K citations
Chinese Academy of Sciences
Beijing, China
3 h-index
9 publications
584 citations
Centre National de la Recherche Scientifique
Paris, France
3 h-index
9 publications
895 citations
Georgia Institute of Technology
Atlanta, United States
3 h-index
5 publications
568 citations
University of Gothenburg
Gothenburg, Sweden
2 h-index
13 publications
274 citations
University College London
London, United Kingdom
2 h-index
14 publications
2.6K citations
National Hospital for Neurology and Neurosurgery
London, United Kingdom
2 h-index
10 publications
1.4K citations
1–8 of 209
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- Journal of Molecular Biology
JMB · 4 publications · 408 citations
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- Scientific Reports
4 publications · 146 citations
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- Journal of Cell Science
3 publications · 194 citations
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- Journal of Biological Chemistry
JBC · 3 publications · 606 citations
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- Nature
2 publications · 2.7K citations
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