Concepedia

Protein Aggregation Toxicity

Protein Aggregation Toxicity is a pathophysiological mechanism, within the context of protein folding disorders, in which the accumulation of misfolded protein aggregates exerts cytotoxic effects through disruption of cellular homeostasis, impairment of proteostasis networks, and induction of organelle dysfunction.

148

Publications

14.5K

Citations

821

Authors

306

Institutions

Publications per year

2017–2026

39

Parents

Publications

148

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature · 2002 · 2.4K citations

, , +17

Opposing Activities Protect Against Age-Onset Proteotoxicity

Ehud Cohen, Jan Bieschke, Rhonda M. Perciavalle et al. · Science · 2006 · 858 citations · Full text

, , +17

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in <i>Caenorhabditis</i> <i>elegans</i>

James F. Morley, Heather R. Brignull, Jill J. Weyers et al. · Proceedings of the National Academy of Sciences · 2002 · 831 citations · Full text

, , +17

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

J. Paul Taylor · Human Molecular Genetics · 2003 · 430 citations · Full text

, , +16

Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function

Heather M. Snyder, Kwame Mensah, Catherine Theisler et al. · Journal of Biological Chemistry · 2003 · 417 citations · Full text

, , +16

1–5 of 148

Authors

821

  1. RI
    Richard I. Morimoto

    Northwestern University, United States

    5 publications · 1.2K citations

    5

    h-index

  2. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    5 publications · 3.2K citations

    5

    h-index

  3. FC
    Fabrizio Chiti

    University of Florence, Italy

    5 publications · 3.2K citations

    5

    h-index

  4. CC
    Cristina Cecchi

    University of Florence, Italy

    4 publications · 440 citations

    4

    h-index

  5. MS
    Massimo Stefani

    University of Florence, Italy

    4 publications · 2.9K citations

    4

    h-index

1–5 of 821

Institutions

306

  1. University of Cambridge

    Cambridge, United Kingdom

    9 h-index

    40 publications

    11.6K citations

  2. Northwestern University

    Evanston, United States

    7 h-index

    26 publications

    6.3K citations

  3. University of Florence

    Florence, Italy

    7 h-index

    33 publications

    23K citations

  4. Rice Institute

    Hebron, United States

    5 h-index

    16 publications

    4.7K citations

  5. Harvard University

    Cambridge, United States

    4 h-index

    13 publications

    1.1K citations

  6. Max Planck Institute of Biochemistry

    Martinsried, Germany

    4 h-index

    22 publications

    5.2K citations

  7. National Institutes of Health

    Bethesda, United States

    4 h-index

    14 publications

    726 citations

  8. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    10 publications

    204 citations

1–8 of 306

Venues

  1. PLoS ONE

    9 publications · 185 citations

    9

    h-index

  2. Journal of Biological Chemistry

    JBC · 8 publications · 1.5K citations

    8

    h-index

  3. Scientific Reports

    7 publications · 176 citations

    7

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.9K citations

    7

    h-index

  5. Journal of Cell Science

    6 publications · 447 citations

    6

    h-index

1–5