Heather R. Brignull

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in <i>Caenorhabditis</i> <i>elegans</i>

James F. Morley, Heather R. Brignull, Jill J. Weyers et al. · Proceedings of the National Academy of Sciences · 2002 · 831 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases

Tali Gidalevitz, Anat Ben‐Zvi, Kim H. Ho et al. · Science · 2006 · 651 citations

Life Sciences, Biochemistry, Molecular Biology +17

Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal<i>Caenorhabditis elegans</i>Model

Heather R. Brignull, Finola E. Moore, Stephanie J. Tang et al. · Journal of Neuroscience · 2006 · 213 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

Andreia Teixeira‐Castro, Michael Ailion, Ana Jalles et al. · Human Molecular Genetics · 2011 · 113 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Modeling Polyglutamine Pathogenesis in C. elegans

Heather R. Brignull, James F. Morley, Susana M. D. A. Garcia et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 2006 · 98 citations

Life Sciences, Genetics, Molecular Genetics +9