Richard I. Morimoto

Geroscience: Linking Aging to Chronic Disease

Brian K. Kennedy, Shelley L. Berger, Anne Brunet et al. · Cell · 2014 · 2.7K citations · Full text

Education, Geriatric Medicine, Aging +11

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Helen M. Beere, Beni B. Wolf, Kelvin Cain et al. · Nature Cell Biology · 2000 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +16

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Alexander V. Misharin, Luisa Morales‐Nebreda, Paul A. Reyfman et al. · The Journal of Experimental Medicine · 2017 · 1.1K citations · Full text

Veterinary Medicine, Cell Biology, Pathobiology +17

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

Kevin D. Sarge, Shawn P. Murphy, Richard I. Morimoto · Molecular and Cellular Biology · 1993 · 876 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in <i>Caenorhabditis</i> <i>elegans</i>

James F. Morley, Heather R. Brignull, Jill J. Weyers et al. · Proceedings of the National Academy of Sciences · 2002 · 831 citations · Full text

Life Sciences, Genetics, Molecular Biology +17