Kelvin Cain

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Helen M. Beere, Beni B. Wolf, Kelvin Cain et al. · Nature Cell Biology · 2000 · 1.5K citations · Full text

Inhibits Apoptosis, Signal Transduction, Apaf-1 Apoptosome +11

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

Maria Feoktistova, Peter Geserick, Beate Kellert et al. · Molecular Cell · 2011 · 837 citations · Full text

Apoptosis, Immunology, Cell Death Pathways +16

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

Tencho Tenev, Katiuscia Bianchi, Maurice Darding et al. · Molecular Cell · 2011 · 805 citations · Full text

Genotoxic Stress, Systems Biology, Signal Transduction +9

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Laura S. Dickens, Robert S. Boyd, Rebekah Jukes‐Jones et al. · Molecular Cell · 2012 · 330 citations · Full text

Mitophagy, Caspase-8 Chain Assembly, Apoptosis +18

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

Kelvin Cain, Shawn B. Bratton, Claudia Langlais et al. · Journal of Biological Chemistry · 2000 · 315 citations · Full text