Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Helen M. Beere, Beni B. Wolf, Kelvin Cain, +7

Nature Cell Biology

Inhibits ApoptosisSignal TransductionApaf-1 ApoptosomeProtein FunctionMedicine +9

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

Maria Feoktistova, Peter Geserick, Beate Kellert, +7

Molecular Cell

ApoptosisImmunologyCell Death PathwaysCell DeathInflammation +14

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

Tencho Tenev, Katiuscia Bianchi, Maurice Darding, +8

Molecular Cell

Genotoxic StressSystems BiologySignal TransductionNatural SciencesApoptosis +7

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Laura S. Dickens, Robert S. Boyd, Rebekah Jukes‐Jones, +6

Molecular Cell

MitophagyCaspase-8 Chain AssemblyApoptosisImmunologyCell Death +16

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

Kelvin Cain, Shawn B. Bratton, Claudia Langlais, +4

Journal of Biological Chemistry

Caspase Activation Involves the Formation of the Aposome, a Large (∼700 kDa) Caspase-activating Complex

Kelvin Cain, David G. Brown, Claudia Langlais, +1

Journal of Biological Chemistry

ApoptosisCell DeathMolecular BiologyCaspase CleavageCell Death Mechanisms +20

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Michelle A. Hughes, Ian Powley, Rebekah Jukes‐Jones, +7

Molecular Cell

Death Receptor-induced ApoptosisApoptosisMolecular BiologyCell DeathCytoskeleton +15

Characterization of novel markers of senescence and their prognostic potential in cancer

Mohammad Althubiti, Larissa Lezina, Stephanie Carrera, +8

Cell Death and Disease

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

Melania Capasso, Mandeep K. Bhamrah, Tom Henley, +14

Nature Immunology

Signal TransductionBcr-dependent GenerationHeme HomeostasisCell SignalingMedicine +8

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

Takashi Akasaka, Theodore Balasas, Lisa J. Russell, +30

Blood