Concepedia

Aggregation-induced Cytotoxicity

Aggregation-Induced Cytotoxicity is a pathological mechanism in protein misfolding diseases wherein the accumulation of misfolded proteins into insoluble aggregates directly disrupts cellular homeostasis, leading to organelle dysfunction, proteostatic stress, and ultimately cell death.

49

Publications

5.7K

Citations

316

Authors

111

Institutions

Publications per year

2017–2026

14

Parents

Publications

49

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature · 2002 · 2.4K citations

, , +17

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

Pei-Hsien Ren, Jane E. Lauckner, Ioulia Kachirskaia et al. · Nature Cell Biology · 2009 · 405 citations · Full text

, , +10

Prefibrillar Amyloid Protein Aggregates Share Common Features of Cytotoxicity

Monica Bucciantini, Giulia Calloni, Fabrizio Chiti et al. · Journal of Biological Chemistry · 2004 · 369 citations · Full text

, , +17

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch

Shuichi Igarashi, Reiji Koide, Takayoshi Shimohata et al. · Nature Genetics · 1998 · 358 citations

, , +9

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

Songming Chen, Valérie Berthelier, Wen‐Bin Yang et al. · Journal of Molecular Biology · 2001 · 340 citations

, , +8

1–5 of 49

Authors

316

  1. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    5 publications · 2.9K citations

    5

    h-index

  2. FC
    Fabrizio Chiti

    University of Florence, Italy

    4 publications · 2.9K citations

    4

    h-index

  3. MS
    Massimo Stefani

    University of Florence, Italy

    3 publications · 2.9K citations

    3

    h-index

  4. MB
    Monica Bucciantini

    University of Florence, Italy

    3 publications · 2.9K citations

    3

    h-index

  5. BM
    Benedetta Mannini

    University of Cambridge, United Kingdom

    2 publications · 78 citations

    2

    h-index

1–5 of 316

Institutions

111

  1. University of Cambridge

    Cambridge, United Kingdom

    6 h-index

    25 publications

    8.7K citations

  2. University of Florence

    Florence, Italy

    5 h-index

    20 publications

    21.3K citations

  3. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    15 publications

    284 citations

  4. Niigata University

    Niigata, Japan

    2 h-index

    20 publications

    6.8K citations

  5. KU Leuven

    Leuven, Belgium

    2 h-index

    10 publications

    878 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    7 publications

    861 citations

  7. University of Chinese Academy of Sciences

    Beijing, China

    2 h-index

    5 publications

    96 citations

  8. Texas A&M University

    College Station, United States

    2 h-index

    6 publications

    81 citations

1–8 of 111

Venues

  1. Scientific Reports

    3 publications · 91 citations

    3

    h-index

  2. Journal of Cell Science

    2 publications · 174 citations

    2

    h-index

  3. PLoS ONE

    2 publications · 80 citations

    2

    h-index

  4. International Journal of Molecular Sciences

    IJMS · 2 publications · 74 citations

    2

    h-index

  5. Neurobiology of Disease

    2 publications · 86 citations

    2

    h-index

1–5