Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, +10

Science

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Perni, Céline Galvagnion, Alexander S. Maltsev, +20

Proceedings of the National Academy of Sciences

Proteinlipid InteractionNeurodegenerative DiseasesAggregation ProcessBiochemistryMedicine +9

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Roberta Cascella, Serene W. Chen, Alessandra Bigi, +6

Nature Communications

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

Benedetta Mannini, Estefania Mulvihill, Caterina Sgromo, +6

ACS Chemical Biology

Proteinlipid InteractionOligomeric SpeciesProtein AssemblyPeptide EngineeringMolecular Biology +18

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

Benedetta Mannini, Roberta Cascella, Mariagioia Zampagni, +12

Proceedings of the National Academy of Sciences

Protein ChemistryAberrant Protein OligomersProtein FunctionProtein AssemblyBiochemistry +13

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Ryan Limbocker, Sean Chia, Francesco Simone Ruggeri, +22

Nature Communications

Oleuropein aglycone induces autophagy <i>via</i> the AMPK/mTOR signalling pathway: a mechanistic insight

Stefania Rigacci, Caterina Miceli, Chiara Nediani, +7

Oncotarget

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

Elisa Evangelisti, Roberta Cascella, Matteo Becatti, +5

Scientific Reports

Multistep Inhibition of α-Synuclein Aggregation and Toxicity <i>in Vitro</i> and <i>in Vivo</i> by Trodusquemine

Michele Perni, Patrick Flagmeier, Ryan Limbocker, +20

ACS Chemical Biology

Synaptic Transmissionα-Synuclein InclusionsSynaptic SignalingMultistep InhibitionMolecular Pharmacology +19

Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

Roberta Cascella, Claudia Capitini, Giulia Fani, +3

Journal of Biological Chemistry