Michele Perni - Concepedia

Concepedia

Author

Michele Perni

University of Cambridge ORCID

Also Known As

Michele Perni, Perni, Michele

54

Publications

2.9K

Citations

22

H-Index

61

Concepts

All Affiliations

University of Cambridge University of Florence Georgetown University Imperial College London United States Military Academy

MP

About

Michele Perni is an author at University of Cambridge specializing in medicine, neurodegenerative diseases, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	7	7	741
2	Natural Sciences	5	5	623
3	Biochemistry	5	5	648
4	Engineering	1	1	72
5	Social Sciences	1	1	46

Michele Perni

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29

Publications

2.9K

Citations

22

H-Index

	Year	Citations
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Science	2017	666
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity Michele Perni, Céline Galvagnion, Alexander S. Maltsev, Proceedings of the National Academy of Sciences Proteinlipid InteractionNeurodegenerative DiseasesAggregation ProcessBiochemistryMedicine	2017	289
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease Johnny Habchi, Sean Chia, Ryan Limbocker, Proceedings of the National Academy of Sciences	2016	221
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease Johnny Habchi, Paolo Arosio, Michele Perni, Science Advances	2016	209
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels, Science Advances	2020	170
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes Ryan Limbocker, Sean Chia, Francesco Simone Ruggeri, Nature Communications	2019	144
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method Francesco A. Aprile, Pietro Sormanni, Michele Perni, Science Advances	2017	140
Multistep Inhibition of α-Synuclein Aggregation and Toxicity <i>in Vitro</i> and <i>in Vivo</i> by Trodusquemine Michele Perni, Patrick Flagmeier, Ryan Limbocker, ACS Chemical Biology Synaptic Transmissionα-Synuclein InclusionsSynaptic SignalingMultistep InhibitionMolecular Pharmacology	2018	116
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins Urszula Nowicka, Piotr Chrościcki, Karen Stroobants, eLife MitophagyMitochondrial DysfunctionMitochondrial Protein ImportMolecular BiologyCytoskeleton	2021	116
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers Francesco A. Aprile, Pietro Sormanni, Marina Podpolny, Proceedings of the National Academy of Sciences	2020	89

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