Ryan Limbocker

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Perni, Céline Galvagnion, Alexander S. Maltsev et al. · Proceedings of the National Academy of Sciences · 2017 · 299 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

Johnny Habchi, Sean Chia, Ryan Limbocker et al. · Proceedings of the National Academy of Sciences · 2016 · 228 citations · Full text

Life Sciences, Medicinal Chemistry, Neuroscience +17

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels et al. · Science Advances · 2020 · 181 citations · Full text

Life Sciences, Biophysics, Molecular Biology +16

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Ryan Limbocker, Sean Chia, Francesco Simone Ruggeri et al. · Nature Communications · 2019 · 151 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Multistep Inhibition of α-Synuclein Aggregation and Toxicity <i>in Vitro</i> and <i>in Vivo</i> by Trodusquemine

Michele Perni, Patrick Flagmeier, Ryan Limbocker et al. · ACS Chemical Biology · 2018 · 118 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17