Ryan Limbocker

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Perni, Céline Galvagnion, Alexander S. Maltsev et al. · Proceedings of the National Academy of Sciences · 2017 · 289 citations · Full text

Proteinlipid Interaction, Neurodegenerative Diseases, Aggregation Process +11

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

Johnny Habchi, Sean Chia, Ryan Limbocker et al. · Proceedings of the National Academy of Sciences · 2016 · 221 citations · Full text

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels et al. · Science Advances · 2020 · 170 citations · Full text

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Ryan Limbocker, Sean Chia, Francesco Simone Ruggeri et al. · Nature Communications · 2019 · 144 citations · Full text

Multistep Inhibition of α-Synuclein Aggregation and Toxicity <i>in Vitro</i> and <i>in Vivo</i> by Trodusquemine

Michele Perni, Patrick Flagmeier, Ryan Limbocker et al. · ACS Chemical Biology · 2018 · 116 citations · Full text

Synaptic Transmission, α-Synuclein Inclusions, Synaptic Signaling +21