Francesco A. Aprile

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

Nunilo Cremades, Samuel I. A. Cohen, Emma Deas et al. · Cell · 2012 · 881 citations · Full text

The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

Pietro Sormanni, Francesco A. Aprile, Michele Vendruscolo · Journal of Molecular Biology · 2014 · 506 citations

Protein Chemistry, Biochemistry, Protein Assembly +10

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

Serene W. Chen, Srdja Drakulić, Emma Deas et al. · Proceedings of the National Academy of Sciences · 2015 · 459 citations · Full text

Amyloid Oligomers, Structural Characterization, Protein Assembly +17

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Suman De, David C. Wirthensohn, Patrick Flagmeier et al. · Nature Communications · 2019 · 446 citations · Full text

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Perni, Céline Galvagnion, Alexander S. Maltsev et al. · Proceedings of the National Academy of Sciences · 2017 · 289 citations · Full text

Proteinlipid Interaction, Neurodegenerative Diseases, Aggregation Process +11