Francesco A. Aprile

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

Nunilo Cremades, Samuel I. A. Cohen, Emma Deas et al. · Cell · 2012 · 902 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

Pietro Sormanni, Francesco A. Aprile, Michele Vendruscolo · Journal of Molecular Biology · 2014 · 527 citations

Life Sciences, Biochemistry, Protein Biochemistry +14

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

Serene W. Chen, Srdja Drakulić, Emma Deas et al. · Proceedings of the National Academy of Sciences · 2015 · 467 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Suman De, David C. Wirthensohn, Patrick Flagmeier et al. · Nature Communications · 2019 · 452 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Perni, Céline Galvagnion, Alexander S. Maltsev et al. · Proceedings of the National Academy of Sciences · 2017 · 299 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17