Molecular mechanisms of protein aggregation from global fitting of kinetic models

Georg Meisl, Julius B. Kirkegaard, Paolo Arosio, +5

Nature Protocols

Protein ChemistryKinetic ModelsGlobal FittingProtein AssemblyBiochemistry +11

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

Samuel I. A. Cohen, Paolo Arosio, Jenny Presto, +12

Nature Structural & Molecular Biology

BiochemistryProtein FoldingToxic Aβ OligomersNatural SciencesEnzyme Catalysis +6

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

Thomas C. T. Michaels, Anđela Šarić, Samo Curk, +9

Nature Chemistry

Neurodegenerative DiseasesOligomer PopulationsAlzheimer's DiseaseMolecular NeuroscienceProtein Folding +10

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

Paolo Arosio, Thomas C. T. Michaels, Sara Linse, +7

Nature Communications

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

Nikolai Lorenzen, Søren B. Nielsen, Alexander K. Buell, +12

Journal of the American Chemical Society

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

Johnny Habchi, Sean Chia, Ryan Limbocker, +12

Proceedings of the National Academy of Sciences

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

Johnny Habchi, Paolo Arosio, Michele Perni, +11

Science Advances

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

Vaishali Kakkar, Cecilia Månsson, Eduardo Preusser de Mattos, +16

Molecular Cell

Molecular RegulationNatural SciencesDna ReplicationMolecular BiologyS/t-rich Motif +7

Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

Cecilia Månsson, Paolo Arosio, Rasha Hussein, +7

Journal of Biological Chemistry

Molecular Chaperone Dnajb6BiochemistryProtein AssemblyProtein FoldingNatural Sciences +6

The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils

Miriam Linsenmeier, Lenka Faltova, Chiara Morelli, +7

Nature Chemistry

Hnrnpa1 Low-complexity DomainProtein AssemblyMolecular BiologyCytoskeletonProtein Phase Separation +16