Alessandra Bigi

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Roberta Cascella, Serene W. Chen, Alessandra Bigi et al. · Nature Communications · 2021 · 240 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Synthesis and Biological Evaluation of 1,4-Diaryl-2-azetidinones as Specific Anticancer Agents: Activation of Adenosine Monophosphate Activated Protein Kinase and Induction of Apoptosis

Farida Tripodi, Roberto Pagliarin, Gabriele Fumagalli et al. · Journal of Medicinal Chemistry · 2012 · 65 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

Ryan Limbocker, Benedetta Mannini, Francesco Simone Ruggeri et al. · Communications Biology · 2020 · 64 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively

Alessandra Bigi, Lavinia Morosi, Chiara Pozzi et al. · Glycobiology · 2009 · 60 citations

Life Sciences, Biochemistry, Molecular Biology +17

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

Ryan Limbocker, Roxine Staats, Sean Chia et al. · Frontiers in Neuroscience · 2021 · 58 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17