Roxine Staats

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

Ryan Limbocker, Roxine Staats, Sean Chia et al. · Frontiers in Neuroscience · 2021 · 58 citations · Full text

N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates

Rosie Bell, Rebecca J. Thrush, Marta Castellana-Cruz et al. · Biochemistry · 2022 · 49 citations · Full text

Aggregation Behavior, Neurodegenerative Diseases, Resulting Aggregates +12

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

Roxine Staats, Thomas C. T. Michaels, Patrick Flagmeier et al. · Communications Chemistry · 2020 · 45 citations · Full text

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

Sean Chia, Z. Faidon Brotzakis, Robert I. Horne et al. · Molecular Pharmaceutics · 2022 · 39 citations · Full text

Protein Assembly, Molecular Biology, Small-molecule Inhibitors +19

Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning

Robert I. Horne, Ewa A. Andrzejewska, Parvez Alam et al. · Nature Chemical Biology · 2024 · 35 citations · Full text