Z. Faidon Brotzakis

AlphaFold prediction of structural ensembles of disordered proteins

Z. Faidon Brotzakis, Shengyu Zhang, Mhd Hussein Murtada et al. · Nature Communications · 2025 · 85 citations · Full text

Life Sciences, Bioinformatics, Biophysics +14

Accelerating the Calculation of Protein–Ligand Binding Free Energy and Residence Times Using Dynamically Optimized Collective Variables

Z. Faidon Brotzakis, Vittorio Limongelli, Michele Parrinello · Journal of Chemical Theory and Computation · 2018 · 77 citations

Natural Sciences, Chemistry, Pharmacology +16

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

Z. Faidon Brotzakis, Philip R. Lindstedt, Ross Taylor et al. · ACS Central Science · 2021 · 73 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes

Taniya Bhardwaj, Kundlik Gadhave, Shivani Krishna Kapuganti et al. · Nature Communications · 2023 · 49 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning

Robert I. Horne, Ewa A. Andrzejewska, Parvez Alam et al. · Nature Chemical Biology · 2024 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +9