Concepedia

Chemical Genetics

Chemical genetics is a research methodology in molecular and cellular biology that investigates the function of genes and proteins through the targeted application of exogenous small molecule ligands to modulate protein activity in intact cellular and organismal systems.

220

Publications

16.9K

Citations

1.1K

Authors

327

Institutions

Publications per year

2017–2026

32

Variants

Small Molecule Genetics

Parents

Children

Publications

220

Chemical genetics of Plasmodium falciparum

W. Armand Guiguemde, Anang A. Shelat, David C. Bouck et al. · Nature · 2010 · 568 citations · Full text

, , +7

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

Ainslie B. Parsons, Andrés López, Inmar E. Givoni et al. · Cell · 2006 · 529 citations · Full text

, , +12

Genetic Encoding of Bicyclononynes and <i>trans</i>-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

Kathrin Lang, Lloyd Davis, Stephen Wallace et al. · Journal of the American Chemical Society · 2012 · 524 citations · Full text

, , +13

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

Thomas R. Sutter, Yamei Tang, Carrie L. Hayes et al. · Journal of Biological Chemistry · 1994 · 509 citations · Full text

, , +9

PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

Elisabetta Balzi, M. Wang, Serge Leterme et al. · Journal of Biological Chemistry · 1994 · 450 citations · Full text

, , +16

1–5 of 220

Authors

1.1K

  1. SL
    Stuart L. Schreiber

    Harvard University, United States

    12 publications · 2K citations

    12

    h-index

  2. KM
    Kevan M. Shokat

    University of California, San Francisco, United States

    6 publications · 1.4K citations

    6

    h-index

  3. YC
    Young‐Tae Chang

    National University of Singapore, Singapore

    5 publications · 219 citations

    5

    h-index

  4. MA
    Michael A. Foley

    Harvard University, United States

    4 publications · 475 citations

    4

    h-index

  5. KM
    Kevan M. Shokat

    University of California, San Francisco, United States

    4 publications · 518 citations

    4

    h-index

1–5 of 1.1K

Institutions

327

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    19 h-index

    57 publications

    9.7K citations

  2. Harvard University

    Cambridge, United States

    18 h-index

    90 publications

    10.8K citations

  3. University of California, San Francisco

    San Francisco, United States

    15 h-index

    45 publications

    7.8K citations

  4. University of Toronto

    Toronto, Canada

    5 h-index

    23 publications

    6.9K citations

  5. Harvard Stem Cell Institute

    Cambridge, United States

    5 h-index

    14 publications

    1.4K citations

  6. National Cancer Institute

    Bethesda, United States

    5 h-index

    10 publications

    823 citations

  7. Cornell University

    Ithaca, United States

    5 h-index

    26 publications

    4.1K citations

  8. Texas A&M University

    College Station, United States

    5 h-index

    10 publications

    921 citations

1–8 of 327

Venues

  1. Journal of the American Chemical Society

    JACS · 13 publications · 1.6K citations

    13

    h-index

  2. Biochemistry

    12 publications · 951 citations

    12

    h-index

  3. Chemistry & Biology

    10 publications · 893 citations

    10

    h-index

  4. Nucleic Acids Research

    7 publications · 327 citations

    7

    h-index

  5. PLoS ONE

    6 publications · 248 citations

    6

    h-index

1–5

See also

Chemical Genetics

Core Methods

Target Identification

Small Molecules

Applications