Target Validation is an experimental and analytical process in biomedical research that rigorously demonstrates a causal, therapeutically exploitable relationship between modulation of a proposed biological target and a relevant disease phenotype, establishing that target engagement is likely to yield safe and efficacious clinical outcomes.
91
Publications
8K
Citations
831
Authors
374
Institutions
Publications per year
2017–2026
41
Publications
91
miRecords: an integrated resource for microRNA-target interactions
Feifei Xiao, Zhixiang Zuo, Guoping Cai et al. · Nucleic Acids Research · 2008 · 1.5K citations · Full text
Genetic drug target validation using Mendelian randomisation
Amand F. Schmidt, Chris Finan, María Gordillo‐Marañón et al. · Nature Communications · 2020 · 605 citations · Full text
1–5 of 91
Authors
831
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3
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3
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1–5 of 831
Institutions
374
European Bioinformatics Institute
Cambridge, United Kingdom
5 h-index
80 publications
35.7K citations
University College London
London, United Kingdom
5 h-index
38 publications
6.4K citations
Open Targets
Cambridge, United Kingdom
4 h-index
90 publications
44.9K citations
University Medical Center Utrecht
Utrecht, The Netherlands
4 h-index
7 publications
1.4K citations
Harvard University
Cambridge, United States
4 h-index
12 publications
857 citations
Johns Hopkins University
Baltimore, United States
3 h-index
6 publications
566 citations
Broad Institute
Cambridge, United States
3 h-index
29 publications
1.4K citations
University of California San Diego
San Diego, United States
3 h-index
23 publications
1.6K citations
1–8 of 374
Venues
- Nature Communications
7 publications · 875 citations
7
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- Nucleic Acids Research
6 publications · 2.8K citations
6
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- Drug Discovery Today
4 publications · 69 citations
4
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- bioRxiv (Cold Spring Harbor Laboratory)
Repository · 3 publications · 37 citations
3
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- Nature Chemical Biology
3 publications · 561 citations
3
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1–5