Concepedia

On-target Validation

On-Target Validation is a scholarly contribution that constitutes a direct methodological or empirical substantiation of a target’s biological, functional, or mechanistic role within a defined system, distinguishing itself from ancillary approaches by specifically confirming the causal or regulatory relationship attributed to the target without confounding off-target effects.

36

Publications

2K

Citations

198

Authors

85

Institutions

Publications per year

2017–2026

11

Parents

Publications

36

Drug target validation and identification of secondary drug target effects using DNA microarrays

Matthew J. Marton, Joseph L. DeRisi, Holly A. Bennett et al. · Nature Medicine · 1998 · 647 citations

, , +14

Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery

Paul Bamborough, David H. Drewry, Gavin Harper et al. · Journal of Medicinal Chemistry · 2008 · 162 citations · Full text

, , +15

Fluorophore-assisted light inactivation: A high-throughput tool for direct target validation of proteins

Stefan Beck, Takashi Sakurai, Brenda K. Eustace et al. · PROTEOMICS · 2002 · 105 citations

, , +15

CRISPR-Cas9–based target validation for p53-reactivating model compounds

Michael Wanzel, Jonas B. Vischedyk, Miriam P. Gittler et al. · Nature Chemical Biology · 2015 · 92 citations · Full text

, , +15

Substituted 4-Carboxymethylpyroglutamic Acid Diamides as Potent and Selective Inhibitors of Fibroblast Activation Protein

Ting‐Yueh Tsai, Teng‐Kuang Yeh, Xin Chen et al. · Journal of Medicinal Chemistry · 2010 · 71 citations · Full text

, , +13

1–5 of 36

Authors

198

  1. AM
    Albert Mulenga

    Texas A&M University, United States

    2 publications · 97 citations

    2

    h-index

  2. TT
    Theo T. Nikiforov

    Fairchild Semiconductor (United States), United States

    2 publications · 43 citations

    2

    h-index

  3. AW
    Andrea W. Chow

    Fairchild Semiconductor (United States), United States

    2 publications · 43 citations

    2

    h-index

  4. SA
    Steven A. Sundberg

    Fairchild Semiconductor (United States), United States

    2 publications · 43 citations

    2

    h-index

  5. HG
    Henry G. Wada

    Fairchild Semiconductor (United States), United States

    2 publications · 43 citations

    2

    h-index

1–5 of 198

Institutions

85

  1. Fairchild Semiconductor (United States)

    Sunnyvale, United States

    2 h-index

    8 publications

    172 citations

  2. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    5 publications

    194 citations

  3. University of Oxford

    Oxford, United Kingdom

    2 h-index

    2 publications

    100 citations

  4. Texas A&M University

    College Station, United States

    2 h-index

    6 publications

    291 citations

  5. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    3 publications

    138 citations

  6. Agriculture Victoria

    Melbourne, Australia

    1 h-index

    2 publications

    84 citations

  7. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    1 h-index

    2 publications

    94 citations

  8. The Kids Research Institute Australia

    West Perth, Australia

    1 h-index

    5 publications

    95 citations

1–8 of 85

Venues

  1. Drug Discovery Today

    3 publications · 56 citations

    3

    h-index

  2. Journal of Medicinal Chemistry

    3 publications · 279 citations

    3

    h-index

  3. Methods in molecular biology

    Book series · 2 publications · 57 citations

    2

    h-index

  4. Nature Chemical Biology

    2 publications · 126 citations

    2

    h-index

  5. Drug Discovery Today Technologies

    2 publications · 26 citations

    2

    h-index

1–5