Nature Chemical Biology · 2015 · 92 citations · 39 references
Life SciencesGeneticsMolecular BiologyCancer GeneticsGenome EditingMolecular OncologyCancer BiotechnologyCancer GenomicsCrispr-based EngineeringCrispr-cas SystemsTarget ValidationTherapeutic Genome EditingCrispr-cas TherapeuticsCrispr-cas9 Genome EditingCrispr-cas9 ValidationDrug Target ValidationOn-target ValidationTherapeutic Target Validation
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Genome engineering using the CRISPR-Cas9 system
F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.5K citations · Full text
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations
Medicine, Oncology, Pharmacology +15
Mutational landscape and significance across 12 major cancer types
Cyriac Kandoth, Michael D. McLellan, Fabio Vandin et al. · Nature · 2013 · 4.5K citations · Full text
Requirement for p53 and p21 to Sustain G <sub>2</sub> Arrest After DNA Damage
Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations