Concepedia

Drug Target Validation

Drug Target Validation is a methodological process in reverse chemical genetics that confirms the biological relevance and therapeutic potential of a molecular target by establishing a causal relationship between modulating the target and a desired phenotypic outcome.

638

Publications

34.3K

Citations

4.8K

Authors

1.2K

Institutions

Publications per year

2017–2026

260

Parents

Publications

638

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Michael Zengerle, Kwok-Ho Chan, Alessio Ciulli · ACS Chemical Biology · 2015 · 1K citations · Full text

, , +16

Drug target validation and identification of secondary drug target effects using DNA microarrays

Matthew J. Marton, Joseph L. DeRisi, Holly A. Bennett et al. · Nature Medicine · 1998 · 647 citations

, , +14

Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders

Claudia Binda, Paige Newton‐Vinson, František Hubálek et al. · Nature Structural Biology · 2001 · 634 citations

, , +15

Genetic drug target validation using Mendelian randomisation

Amand F. Schmidt, Chris Finan, María Gordillo‐Marañón et al. · Nature Communications · 2020 · 605 citations · Full text

, , +17

Open Targets: a platform for therapeutic target identification and validation

Gautier Koscielny, Peter An, Denise Carvalho‐Silva et al. · Nucleic Acids Research · 2016 · 529 citations · Full text

, , +15

1–5 of 638

Authors

4.8K

  1. IH
    Ian H. Gilbert

    University of Dundee, United Kingdom

    13 publications · 709 citations

    13

    h-index

  2. PG
    Paul G. Wyatt

    University of Dundee, United Kingdom

    10 publications · 629 citations

    10

    h-index

  3. LS
    Leah S. Torrie

    University of Dundee, United Kingdom

    10 publications · 494 citations

    10

    h-index

  4. AH
    Alan H. Fairlamb

    University of Dundee, United Kingdom

    9 publications · 576 citations

    9

    h-index

  5. JA
    Julie A. Frearson

    University of Dundee, United Kingdom

    7 publications · 477 citations

    7

    h-index

1–5 of 4.8K

Institutions

1.2K

  1. University of Dundee

    Dundee, United Kingdom

    27 h-index

    205 publications

    12.7K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    50 publications

    2.3K citations

  3. Heidelberg University

    Heidelberg, Germany

    14 h-index

    80 publications

    3.8K citations

  4. Harvard University

    Cambridge, United States

    13 h-index

    77 publications

    5.4K citations

  5. Inserm

    Paris, France

    12 h-index

    30 publications

    1.1K citations

  6. University of California, San Francisco

    San Francisco, United States

    11 h-index

    29 publications

    2K citations

  7. Monash University

    Melbourne, Australia

    11 h-index

    28 publications

    993 citations

  8. Imperial College London

    London, United Kingdom

    11 h-index

    24 publications

    1.6K citations

1–8 of 1.2K

Venues

  1. Journal of Medicinal Chemistry

    40 publications · 2.3K citations

    28

    h-index

  2. PLoS ONE

    20 publications · 780 citations

    17

    h-index

  3. PubMed

    Repository · 21 publications · 979 citations

    17

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 1.9K citations

    16

    h-index

  5. Antimicrobial Agents and Chemotherapy

    AAC · 17 publications · 823 citations

    15

    h-index

1–5