Concepedia

Reverse Chemical Genetics

Reverse Chemical Genetics is a research strategy within chemical genetics that begins with a bioactive small molecule and proceeds to identify its molecular target and associated biological pathway, thereby establishing a causal link between protein function and phenotype through chemical perturbation.

12

Publications

868

Citations

53

Authors

20

Institutions

Publications per year

2017–2026

0

Variants

Target-based Chemical Genetics

Parents

Children

Publications

12

Chemical Genetics: Where Genetics and Pharmacology Meet

Zachary A. Knight, Kevan M. Shokat · Cell · 2007 · 249 citations · Full text

, , +11

A one-bead, one-stock solution approach to chemical genetics: part 1

Helen E. Blackwell, Lucy Pérez, Robert A. Stavenger et al. · Chemistry & Biology · 2001 · 125 citations · Full text

, , +4

Photo‐Cross‐Linked Small‐Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu et al. · Angewandte Chemie International Edition · 2005 · 120 citations · Full text

, , +16

A one-bead, one-stock solution approach to chemical genetics: part 2

Paul A. Clemons, Angela N. Koehler, Bridget K. Wagner et al. · Chemistry & Biology · 2001 · 107 citations · Full text

, , +4

SAR by ILOEs: An NMR‐Based Approach to Reverse Chemical Genetics

Barbara Becattini, Maurizio Pellecchia · Chemistry - A European Journal · 2005 · 70 citations

, , +11

1–5 of 12

Authors

53

  1. HO
    Hiroyuki Osada

    RIKEN, Japan

    2 publications · 135 citations

    2

    h-index

  2. NK
    Naoki Kanoh

    Tohoku University, Japan

    2 publications · 135 citations

    2

    h-index

  3. KH
    Kaori Honda

    RIKEN Center for Sustainable Resource Science, Japan

    2 publications · 135 citations

    2

    h-index

  4. SL
    Stuart L. Schreiber

    Harvard University, United States

    2 publications · 232 citations

    2

    h-index

  5. MM
    Makoto Muroi

    RIKEN, Japan

    2 publications · 135 citations

    2

    h-index

1–5 of 53

Institutions

20

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    11 publications

    1.5K citations

  2. Harvard Stem Cell Institute

    Cambridge, United States

    2 h-index

    8 publications

    928 citations

  3. Harvard University

    Cambridge, United States

    2 h-index

    15 publications

    1.7K citations

  4. RIKEN Advanced Science Institute

    Kobe, Japan

    2 h-index

    10 publications

    675 citations

  5. Lunenfeld-Tanenbaum Research Institute

    Toronto, Canada

    1 h-index

    1 publications

    15 citations

  6. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    1 h-index

    1 publications

    70 citations

  7. VIB-UGent Center for Plant Systems Biology

    Ghent, Belgium

    1 h-index

    1 publications

    58 citations

  8. University of Toronto

    Toronto, Canada

    1 h-index

    1 publications

    15 citations

1–8 of 20

Venues

  1. Chemistry & Biology

    3 publications · 277 citations

    3

    h-index

  2. Methods in molecular biology

    Book series · 1 publications · 27 citations

    1

    h-index

  3. Cell

    1 publications · 249 citations

    1

    h-index

  4. Diabetes

    1 publications · 20 citations

    1

    h-index

  5. The Arabidopsis Book

    TAB · 1 publications · 58 citations

    1

    h-index

1–5