Concepedia

Cellular Pathway Perturbation

Cellular Pathway Perturbation is a systematic experimental intervention that selectively alters specific molecular components or interactions within a defined cellular signaling or metabolic pathway to elucidate the functional consequences and regulatory dynamics of that pathway in the context of reverse chemical genetics.

35

Publications

5.1K

Citations

213

Authors

108

Institutions

Publications per year

2017–2026

13

Parents

Publications

35

Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network

Trey Ideker, Vésteinn Thórsson, Jeffrey A. Ranish et al. · Science · 2001 · 2.1K citations

, , +15

Perturbation-response genes reveal signaling footprints in cancer gene expression

Michaël Schubert, Bertram Klinger, Martina Klünemann et al. · Nature Communications · 2017 · 1.1K citations · Full text

, , +17

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

Christian H. Holland, Jovan Tanevski, Javier Perales-Patón et al. · Genome biology · 2020 · 354 citations · Full text

, , +17

Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant Therapy

Michael J. Strong, Guorong Xu, Joseph Coco et al. · PLoS Pathogens · 2013 · 159 citations · Full text

, , +17

Sieve element unloading: cellular pathway, mechanism and control

John W. Patrick · Physiologia Plantarum · 1990 · 151 citations

, , +8

1–5 of 35

Authors

213

  1. JS
    Julio Sáez-Rodríguez

    Heidelberg University, Germany

    3 publications · 1.6K citations

    3

    h-index

  2. MK
    Martina Klünemann

    Humboldt-Universität zu Berlin, Germany

    2 publications · 1.2K citations

    2

    h-index

  3. JW
    John W. Patrick

    University of Newcastle Australia, Australia

    2 publications · 165 citations

    2

    h-index

  4. NB
    Nils Blüthgen

    Humboldt-Universität zu Berlin, Germany

    2 publications · 1.2K citations

    2

    h-index

  5. MS
    Michaël Schubert

    The Netherlands Cancer Institute, Netherlands

    2 publications · 1.2K citations

    2

    h-index

1–5 of 213

Institutions

108

  1. European Bioinformatics Institute

    Cambridge, United Kingdom

    3 h-index

    5 publications

    2.8K citations

  2. German Cancer Research Center

    Heidelberg, Germany

    3 h-index

    4 publications

    775 citations

  3. RWTH Aachen University

    Aachen, Germany

    3 h-index

    4 publications

    1.9K citations

  4. Joint Research Centre

    Karlsruhe, Germany

    3 h-index

    4 publications

    1.9K citations

  5. Humboldt-Universität zu Berlin

    Berlin, Germany

    2 h-index

    8 publications

    5.9K citations

  6. Wellcome Sanger Institute

    Cambridge, United Kingdom

    2 h-index

    2 publications

    1.2K citations

  7. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    2 h-index

    8 publications

    5.9K citations

  8. Heidelberg University

    Heidelberg, Germany

    2 h-index

    7 publications

    2.2K citations

1–8 of 108

Venues

  1. Environmental Science & Technology

    2 publications · 157 citations

    2

    h-index

  2. PLoS ONE

    2 publications · 67 citations

    2

    h-index

  3. Physiologia Plantarum

    2 publications · 165 citations

    2

    h-index

  4. Molecular Biology of the Cell

    MBC · 1 publications · 56 citations

    1

    h-index

  5. Infectious Agents and Cancer

    IAC · 1 publications · 49 citations

    1

    h-index

1–5