Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

Carsten Culmsee, Changlian Zhu, Stefan Landshamer, +5

Journal of Neuroscience

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

John L. Stebbins, Surya K. De, Thomas Machleidt, +10

Proceedings of the National Academy of Sciences

Jnk-jip Interaction SiteInsulin SignalingSignaling PathwayJnk-interacting Protein-1Cell Signaling +17

Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL

Barbara Becattini, Shinichi Kitada, Marilisa Leone, +6

Chemistry & Biology

Immunocytochemical TechniqueProapoptotic ActivityDrug TargetingRational DesignMedicine +7

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

Stefan Landshamer, Miriam Hoehn, Nicole D. Barth, +12

Cell Death and Differentiation

MitophagyMolecular NeuroscienceCell SignalingNeuronal Cell DeathMitochondria Causes +11

Efficient synthetic inhibitors of anthrax lethal factor

Martino Forino, Sherida L. Johnson, Dmitri V. Rozanov, +12

Proceedings of the National Academy of Sciences

Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study

Emanuel Fryk, Josefin Olausson, Karin Mossberg, +10

EBioMedicine

Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS

Angela Molinaro, Barbara Becattini, Arianna Mazzoli, +7

Cell Metabolism

Insulin-driven Pi3k-akt SignalingSignal TransductionMolecular PhysiologyPi3kβ ActivitiesSignaling Pathway +8

Boron: A key element in radical reactions

Philippe Renaud, Alice Beauseigneur, Andrea Brecht‐Forster, +10

Pure and Applied Chemistry

Cross-coupling ReactionDerivativesEngineeringPhysicsOrganoboron Derivative +12

Targeting Apoptosis via Chemical Design

Barbara Becattini, Sina Sareth, Dayong Zhai, +4

Chemistry & Biology

Medicinal ChemistryDrug TargetingMedicineNatural SciencesApoptosis +6

Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid

Barbara Becattini, Carsten Culmsee, Marilisa Leone, +8

Proceedings of the National Academy of Sciences

ApoptosisCell DeathOrganic ChemistryBid ActivationChemistry +18