N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Julie A. Frearson, Stephen Brand, Stuart P. McElroy, +23

Nature

SleepSleep DisorderN-myristoyltransferase InhibitorsPharmacologyPharmacotherapy +3

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

Suzannah J. Rihn, Andres Merits, Siddharth Bakshi, +79

PLoS Biology

EngineeringGeneticsImmunologyViral PathogenesisCovid-19 Epidemiology +17

Resolution of the insect ouabain paradox

Leah S. Torrie, Jonathan C. Radford, Tony D. Southall, +4

Proceedings of the National Academy of Sciences

BiologySuch ToxinsInsect Ouabain ParadoxOsmoregulationBiochemistry +13

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

Stuart P. McElroy, Toshifumi Nomura, Leah S. Torrie, +4

PLoS Biology

Firefly LuciferaseImmunologyMolecular BiologyNucleic Acid Amplification TestReporter Assays +14

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña, Barbara Forte, Ryan Choi, +74

Proceedings of the National Academy of Sciences

Discovery of a Novel Class of Orally Active Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors

Stephen Brand, Laura A. T. Cleghorn, Stuart P. McElroy, +17

Journal of Medicinal Chemistry

Chemical Validation of Trypanothione Synthetase

Leah S. Torrie, Susan Wyllie, Daniel Spinks, +7

Journal of Biological Chemistry

Lead Optimization of a Pyrazole Sulfonamide Series of <i>Trypanosoma brucei</i> <i>N</i> -Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stephen Brand, Neil R. Norcross, Stephen Thompson, +18

Journal of Medicinal Chemistry

Pharmacological Validation of <i>N</i>-Myristoyltransferase as a Drug Target in <i>Leishmania donovani</i>

Victoriano Corpas‐López, Sónia Moniz, Michael G. Thomas, +18

ACS Infectious Diseases

Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from <i>Pseudomonas aeruginosa</i>

M.S. Alphey, Lisa Pirrie, Leah S. Torrie, +14

ACS Chemical Biology

Molecular BiologyChemical BiologyEnzymatic ModificationPharmaceutical ChemistryGlucose-1-phosphate Thymidylyltransferase +17