Concepedia

Genetic Target Validation

Genetic Target Validation is a methodological approach in biomedical research that employs genetic perturbations to establish causal relationships between a specific gene and a disease-relevant phenotype, thereby confirming the gene's functional role as a viable therapeutic target.

20

Publications

1.6K

Citations

198

Authors

104

Institutions

Publications per year

2017–2026

9

Parents

Publications

20

Genetic drug target validation using Mendelian randomisation

Amand F. Schmidt, Chris Finan, María Gordillo‐Marañón et al. · Nature Communications · 2020 · 605 citations · Full text

, , +17

Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement

Kumar Gaurav, Sanu Arora, Paula Silva et al. · Nature Biotechnology · 2021 · 287 citations · Full text

, , +17

Mutation Rate and Predicted Phenotypic Target Sizes in Ethylnitrosourea-Treated Mice

Dorothy Concepcion, Kevin L. Seburn, Gen Wen et al. · Genetics · 2004 · 90 citations · Full text

, , +17

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of <i>Mycobacterium tuberculosis</i>

Joanna C. Evans, Carolina Trujillo, Zhe Wang et al. · ACS Infectious Diseases · 2016 · 76 citations · Full text

, , +14

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

Natasha Sienkiewicz, Szymon Jarosławski, Susan Wyllie et al. · Molecular Microbiology · 2008 · 70 citations · Full text

, , +15

1–5 of 20

Authors

198

  1. AF
    Amand F. Schmidt

    University College London, United Kingdom

    2 publications · 617 citations

    2

    h-index

  2. RP
    Riyaz Patel

    University College London, United Kingdom

    2 publications · 617 citations

    2

    h-index

  3. SC
    Sandesh Chopade

    University College London, United Kingdom

    2 publications · 617 citations

    2

    h-index

  4. BT
    Benoît Tyl

    Servier (France), France

    2 publications · 617 citations

    2

    h-index

  5. DF
    Daniel F. Freitag

    Bayer (Germany), Germany

    2 publications · 617 citations

    2

    h-index

1–5 of 198

Institutions

104

  1. University College London

    London, United Kingdom

    2 h-index

    18 publications

    5.6K citations

  2. Plateforme Technologique d'Innovation Biomédicale

    Pessac, France

    2 h-index

    2 publications

    617 citations

  3. Servier (France)

    Neuilly-sur-Seine, France

    2 h-index

    2 publications

    617 citations

  4. Bayer (Germany)

    Leverkusen, Germany

    2 h-index

    2 publications

    617 citations

  5. Washington University in St. Louis

    St Louis, United States

    2 h-index

    28 publications

    588 citations

  6. Incyte (United States)

    Wilmington, United States

    2 h-index

    4 publications

    84 citations

  7. University Medical Center Utrecht

    Utrecht, The Netherlands

    2 h-index

    4 publications

    1.2K citations

  8. University of Michigan

    Ann Arbor, United States

    2 h-index

    2 publications

    42 citations

1–8 of 104

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 24 citations

    2

    h-index

  2. Nature Biotechnology

    1 publications · 287 citations

    1

    h-index

  3. Assay and Drug Development Technologies

    1 publications · 12 citations

    1

    h-index

  4. Eukaryotic Cell

    1 publications · 29 citations

    1

    h-index

  5. Molecular and Biochemical Parasitology

    1 publications · 42 citations

    1

    h-index

1–5