Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Barbara Bosch, Michael A. DeJesus, Nicholas C. Poulton, +12

Cell

Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes

Eachan O. Johnson, Emily LaVerriere, Emma Office, +41

Nature

Medicinal ChemistryAntimicrobial Drug DiscoveryPulmonary TuberculosisMedicineTuberculosis Prevention +7

An outer membrane channel protein of <i>Mycobacterium tuberculosis</i> with exotoxin activity

Olga Danilchanka, Jim Sun, Mikhail Pavlenok, +12

Proceedings of the National Academy of Sciences

BacteriologyImmunologyMolecular BiologyCell DeathMedical Microbiology +17

Cytoskeletal Changes in Hypoxic Pulmonary Endothelial Cells Are Dependent on MAPK-activated Protein Kinase MK2

Usamah S. Kayyali, Corin M. Pennella, Carolina Trujillo, +3

Journal of Biological Chemistry

Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice

Joeli Marrero, Carolina Trujillo, Kyu Y. Rhee, +1

PLoS Pathogens

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in <i>Mycobacterium tuberculosis</i>

Susan Puckett, Carolina Trujillo, Zhe Wang, +7

Proceedings of the National Academy of Sciences

Simultaneous Analysis of Multiple Mycobacterium tuberculosis Knockdown Mutants In Vitro and In Vivo

Antje Blumenthal, Carolina Trujillo, Sabine Ehrt, +1

PLoS ONE

Tuberculosis PreventionBacteriologyMolecular BiologyDrug ResistanceMedical Microbiology +15

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

Kan Lin, Kathryn O’Brien, Carolina Trujillo, +4

PLoS Pathogens

Minor RoleCell DeathThiol Redox HomeostasisMtb Pathogenesis RemainRedox Biology +14

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of <i>Mycobacterium tuberculosis</i>

Joanna C. Evans, Carolina Trujillo, Zhe Wang, +7

ACS Infectious Diseases

EngineeringBacteriologyMolecular BiologyDrug ResistanceMedical Microbiology +17

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Susan Puckett, Carolina Trujillo, Hyungjin Eoh, +6

PLoS Pathogens

EngineeringGlycobiologyMicrobial PhysiologyMetabolic ModelMtb Strain +17