Concepedia

Structural Target Characterization

Structural Target Characterization is a methodological framework within target validation that delineates the three-dimensional molecular architecture and functional epitopes of a biological target to enable precise assessment of its druggability, selectivity, and mechanistic role in disease pathways.

117

Publications

5.5K

Citations

744

Authors

309

Institutions

Publications per year

2017–2026

45

Parents

Publications

117

A specific antidote for dabigatran: functional and structural characterization

Felix Schiele, Joanne van Ryn, Keith A. Canada et al. · Blood · 2013 · 561 citations · Full text

, , +9

Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors

J. A. Bertrand, Sandrine Thieffine, Anna Vulpetti et al. · Journal of Molecular Biology · 2003 · 314 citations

, , +12

Structural basis for the action of the drug trametinib at KSR-bound MEK

Z.M. Khan, Alexander M. Real, William M. Marsiglia et al. · Nature · 2020 · 172 citations · Full text

, , +9

Synthesis, structural characterization and in vitro cytotoxicity and anti-bacterial activity of some copper(I) complexes with N,N′-disubstituted thioureas

Muhammad Khawar Rauf, Imtiaz Ud Din, Amin Badshah et al. · Journal of Inorganic Biochemistry · 2009 · 138 citations

, , +8

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

Martin Marek, T.B. Shaik, Tino Heimburg et al. · Journal of Medicinal Chemistry · 2018 · 118 citations · Full text

, , +15

1–5 of 117

Authors

744

  1. FS
    Franciszek Sa̧czewski

    Gdańsk Medical University, Poland

    4 publications · 199 citations

    4

    h-index

  2. AB
    Amin Badshah

    Quaid-i-Azam University, Pakistan

    3 publications · 199 citations

    3

    h-index

  3. ZB
    Zdzisław Brzozowski

    Gdańsk Medical University, Poland

    3 publications · 85 citations

    3

    h-index

  4. SH
    S.K. Hadjikakou

    University of Ioannina, Greece

    3 publications · 240 citations

    3

    h-index

  5. SL
    Shu Liu

    Chinese Academy of Sciences, China

    2 publications · 60 citations

    2

    h-index

1–5 of 744

Institutions

309

  1. Quaid-i-Azam University

    Islamabad, Pakistan

    6 h-index

    19 publications

    862 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    18 publications

    1.5K citations

  3. Gdańsk Medical University

    Gdansk, Poland

    4 h-index

    8 publications

    393 citations

  4. Universidade de São Paulo

    São Paulo, Brazil

    3 h-index

    7 publications

    259 citations

  5. University of Ioannina

    Ioannina, Greece

    3 h-index

    23 publications

    1.9K citations

  6. Ondokuz Mayıs University

    Samsun, Türkiye

    2 h-index

    3 publications

    86 citations

  7. Guangdong Pharmaceutical University

    Guangzhou, China

    2 h-index

    16 publications

    956 citations

  8. National and Kapodistrian University of Athens

    Athens, Greece

    2 h-index

    2 publications

    93 citations

1–8 of 309

Venues

  1. Journal of Molecular Structure

    14 publications · 387 citations

    11

    h-index

  2. European Journal of Medicinal Chemistry

    7 publications · 281 citations

    7

    h-index

  3. Inorganica Chimica Acta

    7 publications · 151 citations

    7

    h-index

  4. Bioorganic & Medicinal Chemistry

    5 publications · 230 citations

    5

    h-index

  5. 5

    h-index

1–5