Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Mark A. Huffman, Anna Fryszkowska, Oscar Alvizo, +32

Science

Enzyme-catalyzed ReactionsBiomanufacturingBiosynthesisEngineeringBiochemistry +13

A specific antidote for dabigatran: functional and structural characterization

Felix Schiele, Joanne van Ryn, Keith A. Canada, +5

Blood

Directed Evolution of Toluene <i>ortho</i> -Monooxygenase for Enhanced 1-Naphthol Synthesis and Chlorinated Ethene Degradation

Keith A. Canada, Sachiyo Iwashita, Hojae Shim, +1

Journal of Bacteriology

Aerobic degradation of tetrachloroethylene by toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1

Doohyun Ryoo, Hojae Shim, Keith A. Canada, +2

Nature Biotechnology

Pseudomonas Stutzeri Ox1Advanced Oxidation ProcessChemical EngineeringEngineeringEnvironmental Engineering +7

A kinase-cGAS cascade to synthesize a therapeutic STING activator

John A. McIntosh, Zhijian Liu, Brian M. Andresen, +58

Nature

Signal TransductionBiochemistryReceptor Tyrosine KinaseKinase-cgas CascadeVenomics +3

Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody

Sanjaya Singh, Rachel Kroe‐Barrett, Keith A. Canada, +11

mAbs

ImmunologyImmune RegulationSelective TargetingImmunologic MechanismImmune System +16

Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies

Rajkumar Ganesan, Ernest Raymond, Detlev Mennerich, +19

mAbs

ImmunologyImmune RegulationImmunodominanceImmunotherapeuticsInnate Immunity +24

DABIGATRAN ANTICOAGULANT ACTIVITY IS NEUTRALIZED BY AN ANTIBODY SELECTIVE TO DABIGATRAN IN IN VITRO AND IN VIVO MODELS

Joanne van Ryn, Tobias Litzenburger, Alisa Waterman, +6

Journal of the American College of Cardiology

ThrombosisHematologyPharmacologyImmunologyTherapeutic Efficacy +8

Rhizosphere Competitiveness of Trichloroethylene-Degrading, Poplar-Colonizing Recombinant Bacteria

Hojae Shim, Sadhana Chauhan, Doohyun Ryoo, +5

Applied and Environmental Microbiology

A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Anna Fryszkowska, Chihui An, Oscar Alvizo, +34

Science

EngineeringBiochemistryProtein FoldingHigh Site SelectivityPenicillin G +12