A kinase-cGAS cascade to synthesize a therapeutic STING activator

John A. McIntosh, Zhijian Liu, Brian M. Andresen, +58

Nature

Signal TransductionBiochemistryReceptor Tyrosine KinaseKinase-cgas CascadeVenomics +3

Palladium and Raney Nickel Catalyzed Methanolic Cleavage of Stable Borane−Amine Complexes

Michel Couturier, John L. Tucker, Brian M. Andresen, +2

Organic Letters

Inorganic ChemistryChemical EngineeringBorane-amine AdductsEngineeringCoordination Complex +10

De Novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study

Brian M. Andresen, J. Du Bois

Journal of the American Chemical Society

De Novo SynthesisChemical BiologyOptogeneticsMolecular PharmacologyMedicinal Chemistry +16

Fluorescent Saxitoxins for Live Cell Imaging of Single Voltage-Gated Sodium Ion Channels beyond the Optical Diffraction Limit

Alison E. Ondrus, Hsiao‐lu D. Lee, Shigeki Iwanaga, +4

Chemistry & Biology

Live Cell ImagingMicroscopyMicroscopy MethodBiomedical ImagingIon Channels +11

A mass spectrometry-based proteome map of drug action in lung cancer cell lines

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, +17

Nature Chemical Biology

Proteomic TechnologyBiochemistryTumor MicroenvironmentMedicineNatural Sciences +10

The use of borane–amine adducts as versatile palladium-catalyzed hydrogen-transfer reagents in methanol

Michel Couturier, Brian M. Andresen, John L. Tucker, +3

Tetrahedron Letters

Chemical EngineeringEngineeringMethanolOrganic ChemistryBorane–amine Adducts +6

Streamlined Processes for the Synthesis of a Farnesyl Transferase Inhibitor Drug Candidate

Brian M. Andresen, Michel Couturier, Brian J. Cronin, +16

Organic Process Research & Development

Combinatorial ChemistryFarnesyl TransferaseInitial SynthesisQuinolinone D-tartrate 2Organic Chemistry +14

Phosphine-Mediated [4 + 2] Annulation of Bis(enones):  A Lewis Base Catalyzed “Mock Diels−Alder” Reaction

Michel Couturier, Fréderic Ménard, John A. Ragan, +6

Organic Letters

Lewis-base-catalyzed CycloisomerizationChemical EngineeringEngineeringDiels-alder CycloadditionTraditional Lewis Acid +8

Practical Large-Scale Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate:  Atom Economical Self-Hydrogenolysis of a Crystalline Borane−Benzylamine Adduct

Michel Couturier, Brian M. Andresen, Jeffrey B. Jorgensen, +6

Organic Process Research & Development

Diversity Oriented SynthesisEngineeringBiochemistryPractical Large-scale SynthesisEfficient Four-step Sequence +13

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

G. Smith, Michael D. Altman, Brian M. Andresen, +29

Bioorganic & Medicinal Chemistry Letters

InflammationMedicinal ChemistryAnti-inflammatoryPharmacologyImmunology +6