John A. McIntosh

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

John A. McIntosh, Pedro S. Coelho, Christopher C. Farwell et al. · Angewandte Chemie International Edition · 2013 · 289 citations · Full text

Deep Dive into Machine Learning Models for Protein Engineering

Yuting Xu, Deeptak Verma, Robert P. Sheridan et al. · Journal of Chemical Information and Modeling · 2020 · 218 citations

Deep Dive, Engineering, Machine Learning +18

Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450

Christopher C. Farwell, Ruijie K. Zhang, John A. McIntosh et al. · ACS Central Science · 2015 · 181 citations · Full text

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

John A. McIntosh, Tamas Benkovics, Steven M. Silverman et al. · ACS Central Science · 2021 · 179 citations · Full text

Bioorganic Chemistry, Engineering, Synthetic Virology +19

Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination

Todd K. Hyster, Christopher C. Farwell, Andrew R. Buller et al. · Journal of the American Chemical Society · 2014 · 177 citations · Full text

Aldo-keto Reductase, Engineered Active Site, Cytochrome P450bm3 +8