Concepedia

Synthetic Lethality

Synthetic lethality is a genetic interaction in which the combination of two non-lethal gene perturbations results in cell death, distinguishing it from single-gene effects by its dependence on the simultaneous disruption of complementary molecular pathways.

2.1K

Publications

155K

Citations

14.7K

Authors

2.3K

Institutions

Publications per year

2017–2026

793

Parents

Children

Publications

2.1K

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers

Peter C.C. Fong, David S. Boss, Timothy A. Yap et al. · New England Journal of Medicine · 2009 · 3.6K citations · Full text

, , +17

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell · Chemistry & Biology · 2008 · 1.9K citations · Full text

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Adjuvant Olaparib for Patients with <i>BRCA1</i> - or <i>BRCA2</i> -Mutated Breast Cancer

Andrew Tutt, Judy E. Garber, Bella Kaufman et al. · New England Journal of Medicine · 2021 · 1.7K citations · Full text

, , +17

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Sonam Dolma, Stephen L. Lessnick, William C. Hahn et al. · Cancer Cell · 2003 · 1.4K citations · Full text

, , +13

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

Ji Luo, Michael J. Emanuele, Danan Li et al. · Cell · 2009 · 1K citations

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1–5 of 2.1K

Authors

14.7K

  1. CJ
    Christopher J. Lord

    Institute of Cancer Research, United Kingdom

    31 publications · 4.8K citations

    28

    h-index

  2. AA
    Alan Ashworth

    Institute of Cancer Research, United Kingdom

    25 publications · 8.3K citations

    24

    h-index

  3. RB
    Rachel Brough

    Breast Cancer Now, United Kingdom

    19 publications · 3.5K citations

    19

    h-index

  4. SM
    Srinivasan Madhusudan

    University of Nottingham, United Kingdom

    14 publications · 664 citations

    14

    h-index

  5. CB
    Charles Boone

    University of Toronto, Canada

    15 publications · 1.6K citations

    14

    h-index

1–5 of 14.7K

Institutions

2.3K

  1. Harvard University

    Cambridge, United States

    58 h-index

    565 publications

    98.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    47 h-index

    193 publications

    43K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    46 h-index

    409 publications

    76.8K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    45 h-index

    494 publications

    54.7K citations

  5. Broad Institute

    Cambridge, United States

    35 h-index

    409 publications

    62.4K citations

  6. Institute of Cancer Research

    London, United Kingdom

    34 h-index

    346 publications

    85.2K citations

  7. National Cancer Institute

    Bethesda, United States

    32 h-index

    223 publications

    24.6K citations

  8. University of Toronto

    Toronto, Canada

    31 h-index

    225 publications

    26.6K citations

1–8 of 2.3K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 90 publications · 10.6K citations

    56

    h-index

  2. Molecular and Cellular Biology

    MCB · 88 publications · 7.2K citations

    53

    h-index

  3. Cancer Research

    77 publications · 6.9K citations

    50

    h-index

  4. Nature Communications

    64 publications · 6.3K citations

    45

    h-index

  5. Genetics

    125 publications · 6K citations

    44

    h-index

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