Rachel Brough

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

Joaquı́n Mateo, Suzanne Carreira, Shahneen Sandhu et al. · New England Journal of Medicine · 2015 · 2.1K citations · Full text

Resistance to therapy caused by intragenic deletion in BRCA2

Stacey L. Edwards, Rachel Brough, Christopher J. Lord et al. · Nature · 2008 · 979 citations

Intragenic Deletion, Oncogenic Agent, Pathology +4

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer, Salomé Adam, Dheva Setiaputra et al. · Nature · 2018 · 635 citations · Full text

Chromatin, Genome Instability, Chromatin Remodeling +4

Synthetic lethal targeting of <i>PTEN</i> mutant cells with PARP inhibitors

Ana M. Mendes‐Pereira, Sarah A. Martin, Rachel Brough et al. · EMBO Molecular Medicine · 2009 · 618 citations · Full text

Drug Targeting, Synthetic Lethal Targeting, Molecular Biology +7

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma et al. · Nature Communications · 2018 · 435 citations · Full text