Stephen J. Pettitt

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer, Salomé Adam, Dheva Setiaputra et al. · Nature · 2018 · 635 citations · Full text

Chromatin, Genome Instability, Chromatin Remodeling +4

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma et al. · Nature Communications · 2018 · 435 citations · Full text

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

Stephen J. Pettitt, Qi Liang, Xin Y. Rairdan et al. · Nature Methods · 2009 · 385 citations · Full text

Developmental Biology, Medicine, Stem Cell Research +5

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Diana Zatreanu, Helen M.R. Robinson, Omar Alkhatib et al. · Nature Communications · 2021 · 336 citations · Full text

Structural basis for allosteric PARP-1 retention on DNA breaks

Levani Zandarashvili, Marie-France Langelier, Uday Kiran Velagapudi et al. · Science · 2020 · 315 citations · Full text