Chemistry & Biology · 2008 · 1.9K citations · 26 references
MedicineCancer BiologyOncologyApoptosisMolecular OncologyOncogenesApoptosis In CancerCell DeathOncogene ActivationRas Family OncogenesSynthetic LethalitySynthetic Lethality In CancerCell Death In CancerOncogenic Ras MutationsSynthetic Lethal ScreeningSynthetic Lethality AnalysisSynthetic Lethality In Oncogenes
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations
Creation of human tumour cells with defined genetic elements
William C. Hahn, Christopher M. Counter, Ante S. Lundberg et al. · Nature · 1999 · 2.3K citations
Medicine, Cancer Biology, Genetics +13
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Amy H.Y. Tong, Marie Evangelista, Ainslie B. Parsons et al. · Science · 2001 · 2.2K citations
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
Jason Moffat, Dorre A. Grueneberg, Xiaoping Yang et al. · Cell · 2006 · 1.9K citations · Full text
RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
Nicholas Yagoda, Moritz von Rechenberg, Elma Zaganjor et al. · Nature · 2007 · 1.6K citations · Full text