Concepedia

Synthetic Lethality Analysis

Synthetic Lethality Analysis is a functional genomics method that identifies pairs of genes whose simultaneous inactivation results in cell death, whereas inactivation of either gene alone is non-lethal, thereby revealing genetic interactions critical for cellular survival.

92

Publications

8.8K

Citations

704

Authors

220

Institutions

Publications per year

2017–2026

33

Parents

Publications

92

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell · Chemistry & Biology · 2008 · 1.9K citations · Full text

, , +14

Gene essentiality and synthetic lethality in haploid human cells

Vincent A. Blomen, Peter Májek, Lucas T. Jae et al. · Science · 2015 · 948 citations

, , +17

Synthetic Genetic Array Analysis in <I>Saccharomyces cerevisiae</I>

Amy H.Y. Tong, Charles Boone · Humana Press eBooks · 2005 · 526 citations

, , +17

Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality

Livnat Jerby‐Arnon, Nadja Pfetzer, Yedael Y. Waldman et al. · Cell · 2014 · 306 citations · Full text

, , +16

Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.

Holly V. Goodson, Blake Anderson, Hans M. Warrick et al. · The Journal of Cell Biology · 1996 · 230 citations · Full text

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1–5 of 92

Authors

704

  1. ER
    Eytan Ruppin

    Tel Aviv University, Israel

    5 publications · 670 citations

    5

    h-index

  2. JS
    Joo Sang Lee

    National Cancer Institute, United States

    4 publications · 364 citations

    4

    h-index

  3. CJ
    Colm J. Ryan

    University College Dublin, Ireland

    3 publications · 218 citations

    3

    h-index

  4. CD
    Costas D. Maranas

    Pennsylvania State University, United States

    3 publications · 319 citations

    3

    h-index

  5. SH
    Sridhar Hannenhalli

    University of Pennsylvania, United States

    3 publications · 343 citations

    3

    h-index

1–5 of 704

Institutions

220

  1. Harvard University

    Cambridge, United States

    13 h-index

    67 publications

    7.1K citations

  2. National Cancer Institute

    Bethesda, United States

    9 h-index

    70 publications

    6.1K citations

  3. Center for Cancer Research

    Bethesda, United States

    8 h-index

    46 publications

    4.8K citations

  4. National Institutes of Health

    Bethesda, United States

    8 h-index

    53 publications

    4.9K citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    7 h-index

    45 publications

    5.2K citations

  6. Broad Institute

    Cambridge, United States

    6 h-index

    39 publications

    3.6K citations

  7. Tel Aviv University

    Tel Aviv, Israel

    5 h-index

    17 publications

    2.3K citations

  8. Johns Hopkins University

    Baltimore, United States

    5 h-index

    22 publications

    2K citations

1–8 of 220

Venues

  1. Nucleic Acids Research

    4 publications · 130 citations

    4

    h-index

  2. BMC Systems Biology

    3 publications · 162 citations

    3

    h-index

  3. Nature Communications

    3 publications · 294 citations

    3

    h-index

  4. Molecular Biology of the Cell

    MBC · 3 publications · 97 citations

    3

    h-index

  5. Genetics

    3 publications · 319 citations

    3

    h-index

1–5