Concepedia

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas, Kayan M. Parker, Dan Flower, Elena López‐Knowles, Suzanne Kyle, Mark Meuth, Nicola J. Curtin, Thomas Helleday

Nature · 2005 · 5.2K citations · 23 references

DOI

Concepts

References

23

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.7K citations

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Tanya T. Paull, Emmy P. Rogakou, Vikky Yamazaki et al. · Current Biology · 2000 · 2.1K citations · Full text

, , +17

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

Damien D’Amours, Serge Desnoyers, Icy D’Silva et al. · Biochemical Journal · 1999 · 1.8K citations · Full text

, , +9

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

Josiane Ménissier de Murcia, C. Niedergang, Carlotta Trucco et al. · Proceedings of the National Academy of Sciences · 1997 · 1.1K citations · Full text

, , +17

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

Sherif F. El‐Khamisy · Nucleic Acids Research · 2003 · 656 citations · Full text

, , +14