Thomas Helleday

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

Life Sciences, Cancer Biology, Oncology +12

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 2K citations

Medicine, Cancer Biology, Oncology +16

Replication stress links structural and numerical cancer chromosomal instability

Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder et al. · Nature · 2013 · 918 citations · Full text

Life Sciences, Cancer Biology, Genetics +14

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Eva Petermann, Manuel Luís Orta, Natalia Issaeva et al. · Molecular Cell · 2010 · 832 citations · Full text

Life Sciences, Biology, Molecular Biology +15

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski et al. · Nature Cell Biology · 2005 · 648 citations

Life Sciences, Genetics, Molecular Biology +14