Thomas Helleday

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.1K citations

Tumor Biology, Oncology, Medicine +7

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 1.9K citations

Oncogene-induced Senescence, Chromatin, Genome Instability +11

Replication stress links structural and numerical cancer chromosomal instability

Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder et al. · Nature · 2013 · 896 citations · Full text

Chromatin, Genome Instability, Cell Division +6

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Eva Petermann, Manuel Luís Orta, Natalia Issaeva et al. · Molecular Cell · 2010 · 824 citations · Full text

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski et al. · Nature Cell Biology · 2005 · 646 citations

Genome Instability, Protein Kinase, Cell Cycle +4