Concepedia

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski, Randi G. Syljuåsen, Cecilia Lundin, Jiří Bártek, Thomas Helleday

Nature Cell Biology · 2005 · 648 citations · 29 references

DOI

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References

29

Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

, , +17

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Hui Zhao, Helen Piwnica‐Worms · Molecular and Cellular Biology · 2001 · 1.1K citations · Full text

, , +17

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

Jann N. Sarkaria, Ericka C. Busby, Randal S. Tibbetts et al. · PubMed · 1999 · 1K citations

, , +16

<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

Eric J. Brown, David Baltimore · Genes & Development · 2000 · 944 citations · Full text

, , +17

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

Teruhisa Tsuzuki, Youichi Fujii, Kunihiko Sakumi et al. · Proceedings of the National Academy of Sciences · 1996 · 795 citations · Full text

, , +14