Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas, +7

Nature

Tumor BiologyOncologyMedicinePathologyAnti-cancer Agent +5

Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361

Christopher Calabrese, Robert J. Almassy, Stephen Barton, +18

JNCI Journal of the National Cancer Institute

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial

Huw D. Thomas, Christopher Calabrese, Michael A. Batey, +9

Molecular Cancer Therapeutics

Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors

Asima Mukhopadhyay, Ahmed Elattar, Aiste Cerbinskaite, +7

Clinical Cancer Research

Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2

Yvette Drew, Evan A. Mulligan, Wan-Tse Vong, +9

JNCI Journal of the National Cancer Institute

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

Carol A. Delaney, L Z Wang, Suzanne Kyle, +6

PubMed

Novel Parp InhibitorsPharmacotherapyTumor BiologyMedicinal ChemistryNovel Poly +15

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

Amy Peasland, L-Z Wang, Emily J. Rowling, +8

British Journal of Cancer

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

Nicola J. Curtin, Lan-Zhen Wang, Anthie Yiakouvaki, +8

Clinical Cancer Research

Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, <i>In Vitro</i> and <i>In Vivo</i> in p53 Functional and Dysfunctional Models of Human Cancer

Michael A. Batey, Yan Zhao, Suzanne Kyle, +6

Molecular Cancer Therapeutics

Atm InhibitionOncologyPreclinical EvaluationMedicinePharmacology +13

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure

Stacie S. Canan Koch, Lars Thoresen, Jayashree Tikhe, +22

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryParp-1 ProteinChemical BiologyPolymerase-1 Inhibitors +16