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Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2

DOIFull Paper Access

257

Citations

37

References

2010

Year

Yvette Drew, Evan A. Mulligan, Wan-Tse Vong, Huw D. Thomas, Samra Kahn, Suzanne Kyle, Asima Mukhopadhyay, Gerrit Los, Zdeněk Hostomský, Elizabeth Ruth Plummer,
JNCI Journal of the National Cancer Institute

Abstract

Human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2 were sensitive to AG014699 monotherapy, indicating a potential role for PARP inhibitors in sporadic human cancers.

References

YearCitations

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