Concepedia

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord, Andrew Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights,

Nature · 2005 · 6.7K citations · 17 references

DOI

Concepts

References

17

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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Brca1 Controls Homology-Directed DNA Repair

Mary Ellen Moynahan, Joanne W Chiu, Beverly H. Koller et al. · Molecular Cell · 1999 · 1.2K citations · Full text

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BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Mary Ellen Moynahan, Andrew J. Pierce, Maria Jasin · Molecular Cell · 2001 · 1K citations · Full text

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PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

Jean‐Christophe Amé, Véronique Rolli, Valérie Schreiber et al. · Journal of Biological Chemistry · 1999 · 748 citations · Full text

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The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

Anamitra Bhattacharyya, Uy Ear, Beverly H. Koller et al. · Journal of Biological Chemistry · 2000 · 588 citations · Full text

, , +17