CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Anne E. Carpenter, Thouis R. Jones, Michael R. Lamprecht, +8

Genome biology

A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

Jason Moffat, Dorre A. Grueneberg, Xiaoping Yang, +16

Cell

Viral ReplicationMolecular VirologyImmunologyMouse Genes AppliedLentiviral Rnai Library +7

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Traver Hart, Megha Chandrashekhar, Michael Aregger, +15

Cell

Genotype-specific Cancer LiabilitiesEngineeringGeneticsGenetic EngineeringMolecular Genetics +7

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen, +6

Developmental Cell

Signal TransductionSignaling PathwayCell RegulationMolecular RegulationMtorc Components Raptor +6

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

Gregory Huyer, Susana Liu, John A. Kelly, +6

Journal of Biological Chemistry

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

Marko Škrtić, Shrivani Sriskanthadevan, Bozhena Jhas, +26

Cancer Cell

Hematological MalignancyTranslational MedicineMitochondrial FunctionMitochondrial TranslationMedicine +8

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Traver Hart, Amy H.Y. Tong, Katie Chan, +28

G3 Genes Genomes Genetics

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer, Salomé Adam, Dheva Setiaputra, +29

Nature

ChromatinGenome InstabilityChromatin RemodelingMolecular Biology53Bp1-dependent Dna Repair +2

Exploration of Essential Gene Functions via Titratable Promoter Alleles

Sanié Mnaimneh, Armaity P. Davierwala, Jennifer Haynes, +21

Cell

Essential Gene FunctionsGeneticsGene StructureMolecular GeneticsGene Regulatory Network +4

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

Gagan D. Gupta, Étienne Coyaud, João Gonçalves, +17

Cell

Protein FunctionProtein AssemblyProtein FoldingHuman Centrosome-cilium InterfaceNatural Sciences +9