Concepedia

Megha Chandrashekhar

MC

10

Publications

3.3K

Citations

10

H-Index

2013

Active since

Affiliations

University of Toronto(Current)

Lunenfeld-Tanenbaum Research Institute

Mount Sinai Hospital

Canadian Institute for Advanced Research

The University of Texas MD Anderson Cancer Center

Megha Chandrashekhar is an author at University of Toronto specializing in medicine, crispr, and genome editing.

Top concepts

MedicineCrisprGene EditingGenome EditingGeneticsCell BiologyMolecular BiologyTumor BiologySystems BiologyGenetic Engineering

Publications per year

2013–2022

10

Publications

10

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Traver Hart, Megha Chandrashekhar, Michael Aregger et al. · Cell · 2015 · 1.7K citations · Full text

Genotype-specific Cancer Liabilities, Engineering, Genetics +9

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Traver Hart, Amy H.Y. Tong, Katie Chan et al. · G3 Genes Genomes Genetics · 2017 · 641 citations · Full text

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Michal Zimmermann, Olga Murina, Martin A.M. Reijns et al. · Nature · 2018 · 402 citations · Full text

Natural Sciences, Genetics, Parp-trapping Lesions +10

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar et al. · Nature Medicine · 2016 · 304 citations

Rnf43-mutant Pancreatic Tumors, Signaling Pathway, Genome-wide Crispr Screens +12

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Franco J. Vizeacoumar, Roland Arnold, Frederick S. Vizeacoumar et al. · Molecular Systems Biology · 2013 · 104 citations · Full text

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