cGAS surveillance of micronuclei links genome instability to innate immunity

Karen J. Mackenzie, Paula Carroll, Carol-Anne Martin, +14

Nature

ChromatinSystems BiologyGeneticsInnate Immune SystemMolecular Genetics +6

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Michal Zimmermann, Olga Murina, Martin A.M. Reijns, +21

Nature

Natural SciencesGeneticsParp-trapping LesionsMolecular BiologyDna Replication +8

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Carrie A. Adelman, Rafal L. Lolo, Nicolai J. Birkbak, +11

Nature

Genome InstabilityRad51 Paralogue-dependent RepairGerm Cell LossMedicineImmunology +5

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

John J. Reynolds, Louise S. Bicknell, Paula Carroll, +59

Nature Genetics

Genome InstabilityDevelopmental BiologyGenetic DisorderGeneticsGenomic Mechanism +6

Prolyl Isomerase PIN1 Regulates DNA Double-Strand Break Repair by Counteracting DNA End Resection

Martin Steger, Olga Murina, Daniela Hühn, +11

Molecular Cell

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Margaret E Harley, Olga Murina, Andrea Leitch, +27

Nature Genetics

Genome InstabilityPrimordial DwarfismNatural SciencesGeneticsGenomic Mechanism +9

FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks

Olga Murina, Christine von Aesch, Ufuk Karakus, +4

Cell Reports

RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition

Maria Benitez‐Guijarro, Cesar Lopez‐Ruiz, Žygimantė Tarnauskaitė, +14

The EMBO Journal

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, +9

Nature Communications

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome

David Parry, Lukas Tamayo-Orrego, Paula Carroll, +5

Genes & Development