Karen J. Mackenzie

cGAS surveillance of micronuclei links genome instability to innate immunity

Karen J. Mackenzie, Paula Carroll, Carol-Anne Martin et al. · Nature · 2017 · 1.6K citations · Full text

Chromatin, Systems Biology, Genetics +8

Ribonuclease H2 mutations induce a <scp>cGAS</scp> / <scp>STING</scp> ‐dependent innate immune response

Karen J. Mackenzie, Paula Carroll, Laura A. Lettice et al. · The EMBO Journal · 2016 · 231 citations · Full text

Mutations in <i>COPA</i> lead to abnormal trafficking of STING to the Golgi and interferon signaling

Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan et al. · The Journal of Experimental Medicine · 2020 · 209 citations · Full text

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

Rachel E. Rigby, Lauren M. Webb, Karen J. Mackenzie et al. · The EMBO Journal · 2014 · 155 citations · Full text

Dna Sequencing, Natural Sciences, Genetics +8

Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

Carol-Anne Martin, Jennie Murray, Paula Carroll et al. · Genes & Development · 2016 · 143 citations · Full text

Mitophagy, Brain Development, Genetics +23