Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse, +7

Science

Telomerase ActivityPathologyHuman Telomerase ActivityCell ProliferationCancer Biology +15

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach, +2

Cell

Developmental BiologyOncogenic AgentCellular SenescenceCell ProliferationTumor Suppressor +4

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Andrea Bodnár, Michel Ouellette, Maria Frolkis, +7

Science

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land, Luis F. Parada, Robert A. Weinberg

Nature

Developmental BiologyTumor HeterogeneityLeast TwoOncogenic AgentCell Proliferation +7

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

H. Earl Ruley

Nature

Viral ReplicationDevelopmental BiologyMolecular VirologyVirologyGene Expression +5

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

Tohru Kiyono, Scott A. Foster, Jenn I. Koop, +3

Nature

Developmental BiologyCell RegulationRb/p16ink4a InactivationMedicineTelomerase Activity +6

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

Carmela P. Morales, Shawn E. Holt, Michel M. Ouellette, +6

Nature Genetics

Tumor BiologyOncologyMedicineCancer Cell BiologyPathology +5

Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)

Nayoung Kim

Nucleic Acids Research

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

Xu‐Rong Jiang, Gretchen S. Jimenez, Edwin Chang, +8

Nature Genetics

Telomerase ExpressionHuman CellDevelopmental BiologySomatic VariantSomatic Cell Genetics +5

Dissociation among <i>in vitro</i> telomerase activity, telomere maintenance, and cellular immortalization

Christopher M. Counter, William C. Hahn, Wenyi Wei, +5

Proceedings of the National Academy of Sciences